Art Nouveau Daenerys by Demi Chen
Art Nouveau Daenerys by Demi Chen
My newly made divining tool
My newly made divining tool
This is honestly my favorite Thor moment. He has no idea what that thing is, where he is, what’s going on, but he’s eating pancakes, and the chick with the taser is pointing another electrical thing at him and there are faces on books, but he’s eating pancakes, and yea he’s knows he’s sexy, so yea, he’ll smile.
he doesnt even know what a camera is guys, he just smiles on command
I kind of love asgardians. Most people would be kind of miffed that someone hit them with a car twice and tasered them. He’s just like “SHE HAS BESTED ME IN COMBAT! LET US FEAST TOGETHER!” and I can really get behind that.
Reason #1,450 why I love Thor
The watch of Mary Queen of Scots, c. 16th Century. This Memento-Mori watch presented to Mary Queen of Scots by her attendant Mary Seaton, is from the 16th century. The forehead of the skull is engraved with a figure of death between a palace and a cottage, and a quotation in Latin, “pale death visits with impartial foot the cottages of the poor and castles of the rich”. The skull is held upside down and the jaw lifted to read the silver dial. The hour is struck on a bell. Made by Moyant A. Blois (1570-90). The skull is silver gilt and engraved with figures of death with his scythe and hourglass, Adam and Eve and the crucifixion. The lower part of the skull is pierced to emit the sound when it strikes. The works occupy the brain’s position in the skull fitting into a silver bell which fills the entire hollow of the skull. The hours are struck on this bell by a small hammer.
And it’s period.
Retiring Native American Studies Professor to Be Honored at MSU Pow Wow
At first he wasn’t even going to go to college, but according to a story in the Bozeman Daily Chronicle, it was because of a promise he made to his mother, a Turtle Mountain Chippewa tribal member, who worked as a waitress and maid her whole life, that he started classes at Northern Montana College in Havre.
I’ve always loved women who are unapologetically abrasive
Women people deem as dirty, trashy, and classless
The ones who don’t wash their hair or smile if they don’t feel like it
Women who have a big, metaphorical middle finger in the air because they don’t care if you like them or think they are nice
I will always stand by those women
forever and ever and ever
Danse Macabre by Rob Harrison
First time I’ve seen Death depicted in art as a woman, I quite like it!
Smeared Skies by Matt Molloy
Matt busted out into the art scene with his smeared sky photos. Stacking 100 to 200 photos into one, he gave a new way to enjoy the view above us.
The world’s first clinical trial to explore the use of the hallucinogenic ingredient in magic mushrooms to treat depression is being delayed due to the UK and EU rules on the use of illegal drugs in research.
Professor David Nutt, president of the British Neuroscience Association and Professor of Neuropsychopharmacology at Imperial College London (UK), will tell the BNA’s Festival of Neuroscience today (Sunday) that although the UK’s Medical Research Council has awarded a grant for the trial, the Government’s regulations controlling the licensing of illegal drugs in research and the EU’s guidelines on Good Manufacturing Practice (GMP) have stalled the start of the trial, which was expected to start this year. He is calling for a change to the regulations.
He will tell the meeting at the Barbican in London, that his research has shown that psilocybin, the psychedelic ingredient in magic mushrooms, has the potential to alleviate severe forms of depression in people who have failed to respond fully to other anti-depressant treatments. However, psilocybin is illegal in the UK; the United Nations 1971 Convention on Psychotropic Substances classifies it as a Schedule 1 drug, one that has a high potential for abuse with no recognised medical use, and the UK has classified it as a Class A drug, the classification used for the most dangerous drugs. This means that a special licence has to be obtained to use magic mushrooms in research in the UK, and the manufacture of a synthetic form of psilocybin for use in patients is tightly controlled by EU regulations.
Prof Nutt will say: “The law for the control of drugs like psilocybin as a Schedule 1 Class A drug makes it almost impossible to use them for research and the reason we haven’t started the study is because finding companies who could manufacture the drug and who are prepared to go through the regulatory hoops to get the licence, which can take up to a year and triple the price, is proving very difficult. The whole situation is bedevilled by this primitive, old-fashioned attitude that Schedule 1 drugs could never have therapeutic potential, and so they have to be made impossible to access.”
“The knock-on effect is this profound impairment of research. We are the first people ever to have done a psilocybin study in the UK, but we are still hunting for a company that can manufacture the drug to GMP standards for the clinical trial, even though we’ve been trying for a year to find one. We live in a world of insanity in terms of regulating drugs at present. The whole field is so bogged down by these intransient regulations, so that even if you have a good idea, you may never get it into the clinic.”
He will say that the regulations need to be changed. “Even if I do this study and I show it’s a really useful treatment for some people with depression, there’s only four hospitals in this country that have a licence to hold this drug, so you couldn’t roll out the treatment if it worked because the regulations would make it difficult to use,” he said.
Prof Nutt and his team at Imperial College London (UK) have shown that when healthy volunteers are injected with psilocybin, the drug switched off a front part of the brain called the anterior cingulate cortex, which is known from previous imaging studies to be over-active in depression. “We found that, even in normal people, the more that part of the brain was switched off under the influence of the drug, the better they felt two weeks later. So there was a relationship between that transient switching off of the brain circuit and their subsequent mood,” he will explain. “This is the basis on which we want to run the trial, because this is what you want to do in depression: you want to switch off that over-active part of the brain.
“The other thing we discovered is that the major site of action of the magic mushrooms is to turn down a circuit in the brain called the ‘default mode network’, which the anterior cingulate cortex is part of. The default mode network is a part of the brain between the front and back. It is active when you are thinking about you; it coordinates the thinking and emotional aspects of you.”
The researchers discovered that the ‘default mode network’ had the highest density of 5HT2A receptors in the brain. These are known to be involved in depression and are the targets for a number of existing anti-depressive drugs that aim to improve levels of serotonin – the neurotransmitter  that gives people a sense of well-being and happiness. Psilocybin also acts on these receptors.
“We have found that people with depression have over-active default mode networks, and they are continually locked into a mode of thinking about themselves. So they ruminate on themselves, on their incompetencies, on their badness, that they’re worthless, that they’ve failed; these things are not true, and sometimes they reach delusional levels. This negative rumination may be due to a lack of serotonin and what psilocybin is doing is going in and rapidly replacing the missing serotonin, switching them back into a mind state where they are less ruminating and less depressed,” Prof Nutt will say.
The proposed trial will be for patients with depression who have failed two previous treatments for the condition. Thirty patients will be given a synthetic form of psilocybin and 30 patients will be given a placebo. The drug (or placebo) will be given during two, possibly three, carefully controlled and prepared 30-60 minute sessions. The first session will be a low dose to check there are no adverse responses, the second session will give a higher, therapeutic dose, and then patients can have a third, booster dose in a later session if it’s considered necessary. While they are under the influence of the drug, the patients will have guided talking therapy to enable them to explore their negative thinking and issues that are troubling them. The doctors will follow up the patients for at least a year.
“What we are trying to do is to tap into the reservoir of under-researched ‘illegal’ drugs to see if we can find new and beneficial uses for them in people whose lives are often severely affected by illnesses such as depression. The current legislation is stopping the benefits of these drugs being explored and for the last 40 years we have missed really interesting opportunities to help patients.”
Ethical approval for the trial was granted in March and Prof Nutt says he hopes to be able to start the trial within the next six months – so long as he can find a manufacturer for the drug.
Brace yourselves, it’s time for another visit to the Department of Debilitatingly Awesome Cuteness as we meet Blossom the bat in Queensland, Australia:
Blossom is a Blossom Bat who was rescued after a suspected cat attack and taken to Bat Conservation & Rescue Queensland where, if these photos are any indication, she was lovingly cared for by Louise Saunders.
“Blossom Bats are nectar specialists which feed and groom themselves with the aid of their long tongues. They are known to hover in front of flowers as they forage and are important pollinators of many rainforest plants. A baby at the time of arrival, the little bat was fed a nectar mix recipe and the occasional milk formula. Blossom gradually gained weight and began to practice flying during the night. Often she would dart in and out of rooms and even hover above Louise as she slept before retiring to her little brown bag at dawn.”
We’re pleased to report that the impossibly cute Blossom completely recovered and was eventually released back into the wild on Macleay Island in Queensland, Australia.
Head over to ZooBorns to learn more about Blossom Bats and view even more photos (and video!) of Blossom.